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  • Gleneagles Singapore

Gallbladder and Bile Duct Health
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  • What do my gallbladder and bile duct do?

    gallbladder and bile duct

    What do my gallbladder and bile duct do?

    The liver produces bile, which is used in breaking down the fats in our intestines. This bile is transported from the liver to the gallbladder, where it is stored and concentrated, before being released to the small intestine through the bile duct. During meals, the gallbladder will contract and release concentrated bile through the bile duct into the head of the small intestine, where it can break down the fats in the semi-digested food, and remove bilirubin, a waste product of blood cells breaking down.

    What are gallstones?

    Due to chemical imbalance or infrequent emptying of the bile in the gall bladder, gallstones may develop in the gallbladder. Usually caused by over-concentration of cholesterol or other minerals in the body, gallstones are usually solid masses that are commonly passed out of the body with the stool. However, in some cases, the gallstones may be too big to be passed out of the gallbladder, or they may get lodged in the bile duct, causing a block in the bile duct. When there is a build-up of gallstones in the gallbladder or a block in the bile duct, the gallstones may cause swelling in the respective organs.

    There are 2 main types of gallstones: 

    • Cholesterol stones, the more common type that are usually yellow-green in colour
    • Pigment stones, made of bilirubin (a waste product made when red blood cells are broken down), and are smaller and darker

    What are the causes of gallstones?

    Gallstones form when there are excessive levels of cholesterol or bilirubin inside the gallbladder or when the gallbladder fails to empty completely. These result in tiny crystals developing in the bile that can gradually grow into solid stones.  

    There are several risk factors that make a person more prone to developing gallstones: 

    • Hereditary causes. Having a close family member who has had gallstones  
    • Obesity
    • Rapid weight loss either from ‘crash’ dieting or bariatric surgery
    • Female gender, particularly if you are pregnant, have had children, are taking the combined pill, or are undergoing high-dose oestrogen therapy 
    • Increasing age. Those aged 40 years or older are more likely to have gallstones
    • Medical conditions that affect the flow of bile (cirrhosis, primary sclerosing cholangitis or obstetric cholestasis), diabetes, Crohn’s disease, or irritable bowel syndrome
    • Lifestyle factors. A diet high in fat and cholesterol but low in fibre and not getting much exercise contribute to gallstone formation 

    What are the symptoms of gallstones?

    Gallstones usually do not cause any symptoms until there is blockage of the bile movement, either through an excessive build-up of gallstones in the gallbladder, or a block of the bile duct. When this occurs, symptoms include:

    • Steady, severe pain in the upper right abdomen which can extend to the back and between the shoulder blades
    • Nausea
    • Vomiting
    • Bloating
    • Jaundice (yellowish skin and eyes)

    What are the complications of gallstones?

    • Gallbladder swelling (cholecystitis)
    • Bile duct swelling (cholangitis)
    • Pancreas swelling (pancreatitis)

    How are gallstones diagnosed?

    Diagnosis of gallstones may involve several tests and procedures: 

    • Blood tests to check for signs of inflammation, infection or blockage, and to rule out other conditions.
    • Ultrasound to examine the gallbladder for stones. Abnormalities in the biliary system, including stones or signs of inflammation or infection can be seen.
    • Computerised tomography (CT) scan may be used to look for complications of gallstones. It is often carried out in an emergency to diagnose severe abdominal pain.
    • Endoscopic retrograde cholangiopancreatography (ERCP)uses a small tube known as an endoscope that is run through the mouth into the small intestine to view the bile ducts. Any gallstones found can also be removed during through this procedure. 

    How are gallstones treated?

    Gallstones can be removed laparoscopically (minimally invasive surgery technique), where a special tool is inserted into the gall bladder through a small incision on the stomach. The stones are then removed using these special tools.

    The more common approach is to remove the gallbladder entirely laparoscopically to prevent a repeated development of gallstones. It is possible for someone to live without their gall bladder. Gallbladder removal is also the common treatment for gallbladder swelling caused by gallstones. When the swelling of the gall bladder is left untreated, it is possible for the gallbladder to develop gangrene and rupture. While rare, ruptured gallbladders due to gall bladder inflammation and gallstones have a 30% chance of causing death.

  • Gallbladder and bile duct cancer

    What is gallbladder cancer?

    Gallbladder cancer is the malignant growth of cancer cells in the gall bladder. Similarly, bile duct cancer is the development of cancer in the bile duct.

    What are the causes gallbladder and bile duct cancer?

    People with the following risk factors are more likely to develop gallbladder cancer:

    • Elderly people
    • Females, as gallbladder cancer develops in females more often than men
    • Obesity
    • People who have a history of gallstones
    • Family history of gallbladder cancer

    People with chronic swelling of the bile duct due to infection or blockage are more likely to develop bile duct cancer.

    What are the symptoms of gallbladder and bile duct cancer?

    A common theme of cancer in the biliary system (liver, pancreas, gallbladder and bile duct) is that early stage cancer in these organs tends to have little to no symptoms. The below symptoms tend to develop when the cancer has developed:

    • Steady, severe pain in the upper right abdomen which can extend to the back and between the shoulder blades
    • Nausea
    • Vomiting
    • Bloating
    • Lumps in the abdomen
    • Jaundice (yellowish skin and eyes)

    How is gallbladder and bile duct cancer treated?

    Gallbladder and bile duct cancer can be treated if they are diagnosed early and before they spread extensively to other parts of the body. This is done by removing the cancerous gallbladder, bile duct, or part of the liver. However, cancer in the gallbladder and bile duct is often diagnosed very late due to a lack of regular complete health screenings. In these cases, radiation therapy and chemotherapy are used to control the spread of the cancer and extend the patient’s lifespan.

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